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Nicholas Hulscher, MPH, writing at Dr. Peter McCullough’s Substack, breaks the results of a shocking new study:
Chemotherapy is supposed to kill cancer — not bring it back. But a groundbreaking Cancer Cell study by He et al has revealed that common cancer drugs like doxorubicin and cisplatin can reawaken dormant tumor cells, triggering deadly metastatic relapses — especially in the lungs.
These “sleeping” cancer cells, known as disseminated tumor cells (DTCs), can lie hidden for years before reactivating. This study is the first to directly prove that chemotherapy itself can wake them up.
This new study reveals five key findings:
Chemotherapy Reactivates Dormant Cancer Cells
Using DormTracer, the team showed that chemo-treated mice had a surge of previously dormant cancer cells re-entering the cell cycle.
These reawakened cells formed aggressive lung metastases weeks after chemo — even in cases where the primary tumor was gone.
This effect was specific todormant cells; chemo suppressed active tumors but inadvertently activated the sleeping ones.
Neutrophil Extracellular Traps (NETs) Are the Trigger
Chemotherapy didn’t just hit cancer cells — it also causedfibroblasts in the lungto enter a state called senescence (biological aging).
These senescent cells released pro-inflammatory signals that activated neutrophils — a type of white blood cell.
The neutrophils formedNETs — sticky webs of DNA and enzymes like MMP9 and neutrophil elastase — which remodeled the lung microenvironment and directly triggered dormant DTCs to awaken.
SASP Proteins (C3, MIF, CXCL1) Drive This Chain Reaction
The senescent fibroblasts released a toxic cocktail known as SASP (senescence-associated secretory phenotype).
Three key factors —Complement C3, Macrophage Migration Inhibitory Factor (MIF), and CXCL1 — were identified as major drivers of NET formation.
Mice engineered to lack C3 had far less NET activity and lower rates of metastasis after chemo.
Blocking NETs or Clearing Senescent Cells Prevents Relapse
AdministeringDNase I (which breaks up NETs) or GSK484 (a PAD4 inhibitor that blocks NET formation) completely prevented chemo-triggered metastasis in mice.
GivingDasatinib + Quercetin (a senolytic combo) cleared out the senescent fibroblasts and shut down the entire cascade — resulting in both primary tumor control and no relapse.
Importantly, this combination didn’t reduce chemo’s effectiveness at shrinking the primary tumor.
The Mechanism Was Confirmed in Humans
In breast cancer patients, lung metastases had higher NET density and elevated C3, MIF, and CXCL1 levels after chemotherapy.
Blood samples showed C3 and MIF spiked after treatment — especially in patients who later developed lung relapse.
These markers could becomepredictive biomarkers for relapse risk in future screening.
Hulscher concludes that:
This study flips the script on conventional cancer therapy. Chemotherapy may control the primary tumor — but it can also fuel future metastasis by waking up hidden cancer cells through inflammation and immune activation. Pairing chemo with senolytics or NET-blockers could dramatically reduce relapse — and early trials are already underway.
However, it’s time to explore cancer treatments that don’t harm the entire body and reawaken dormant cancer cells, such as: IVERMECTIN.
A Promising New Treatment
This groundbreaking study should be the beginning of a rush by the medical establishment to look for alternatives to chemotherapy. Unfortunately, chemotherapy is big business for big pharma and the the medical establishment has absolutely no interest in pursuing effective and low-cost treatments.
Fortunately, medical professionals like Dr. Peter McCullough are committed to delivering healthcare solutions that are safe, effective AND affordable. This is exactly why Dr. McCullough and his team are digging in to the potential for ivermectin in combatting cancers.
According to a new study, the early returns are promising. According to the McCullough Foundation:
The study titled “A Review of Ivermectin Use in Cancer Patients: Is it Time to Repurpose the Ivermectin in Cancer Treatment?” was just published in the journal Acta Poloniae Pharmaceutica – Drug Research…
Based on the most comprehensive systematic review of ivermectin use in cancer patients to date, ivermectin appears to be safe—even in individuals undergoing active chemotherapy. Its broad range of anticancer mechanisms demonstrated in preclinical models, combined with anecdotal reports of cancer-related improvements, support its candidacy for repurposing as an oncologic therapy. Well-designed, large-scale clinical trials should be launched as soon as possible to properly assess ivermectin’s potential against cancer.
Indeed, ivermectin in concert with mebendazole has shown even more promise in treating a wide variety of cancers.
Mebendazole, an anti-parasitic like ivermectin, has been prescribed for 100 years to help eradicate parasites – which over 60 million Americans have inside their body today, according to the CDC.
Medication You Can Trust from a Trusted Source
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Note: The information provided on this website is intended for informational purposes only and should not be considered medical advice or used as a substitute for professional healthcare guidance. It is your responsibility to comply with all applicable laws, regulations, and guidelines regarding the purchase, possession, and use of prescription medications.
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